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Biliary Cirrhosis / Bile Duct Cancer Leave a comment

This long-lasting disease damages the bile ducts in your liver. Your doctor may also call it primary biliary cholangitis (PBC). These ducts have an important job. They carry a fluid called bile, which plays a key role in digestion, away from your liver. Bile is what helps your body absorb fats, cholesterol, and even some vitamins. It also helps get rid of worn-outred blood cells and other things your body doesn’t need.


When bile ducts don’t work the way they should, those substances stay in your liver. The bile backs up, and your liver gets inflamedand maybe even scarred. Over time, the scar tissue replaces healthy liver tissue, and the organ doesn’t work the way it should. This is usually a slow and gradual process. Your liver does OK for a while. And you’ll take medications to help it work better and manage your symptoms. But as the disease gets worse, it will begin to fail. This can take a few months or many years. One day, you may need a liver transplant.


What Causes It?

Doctors aren’t totally sure. It isn’t passed down from parents to children, but there does seem to be a family link. It’s more common if you have a parent, brother, or sister who has it. Most people who get it are women, and most are in their 40s and 50s. The disease may be linked to immune system problems like thyroid trouble, pernicious anemia, or scleroderma. Outside factors — smoking, chemicals, or infections — can also trigger the disease.


What Are the Symptoms?

Early on, you might not notice any at all. You can live for many years without problems. Later, you might feel tired or have itchy skin or dry eyes and mouth. As the disease gets worse, you might notice:

•  Yellow skin and eyes (jaundice)

•  Swollen feet and ankles

•  Painand swelling in your abdomen

•  Bone, muscle, or joint pain

•  Darkened skin


How Is It Diagnosed?

If you have any of these symptoms, your doctor might suggest blood tests. They’ll tell her how well your liver works and if you have any immune system issues. She may also want you to have imaging tests like an ultrasound, CT scan, MRI, or X-rays. These provide a more detailed look at your liver and the area around it. She may also suggest a liver biopsy. She’ll remove a small piece of liver tissue and examine it in the lab to look for damage or disease.


How Is It Treated?

There’s no cure, but medications can slow down the disease. The most common drug is ursodiol (ursodeoxycholic acid), which helps move bile through your liver. There are also newer drugs to treat symptoms like itching and fatigue. Your doctor may suggest you make some changes in your daily life. If you drink alcohol, stop. It puts a strain on your liver. Choose low-sodium foods and exercise regularly to ease your symptoms. When medications no longer help, a liver transplant may be an option.

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